Abstract

DO.17.09

Influence of mydriatic eye-drops on wavefront sensing

Taneri S., Stottmeister S.
Zentrum für Refraktive Chirurgie, Münster

Objective: Wavefront-guided ablations are based on wavefront sensing in a pupil dilated under mesopic conditions or in patients with insufficient natural pupil dilation after the application of mydriatic eye-drops.
The aim of the study was to investigate a potential influence of mydriatic eye-drops on wavefront-sensing in terms of the phoropter-predicted-refraction (PPR).
Methods: In this retrospective study 129 myopic eyes were measured in miosis and pharmacologically induced mydriasis with the Zywave aberrometer and automated refraction. 100 eyes were dilated with tropicamide 0.5%+phenylephrine 2.5% eye drops, the remaining 29 with tropicamide 0.5%. The PPR for a pupil diameter of 3.5 mm in miosis and in mydriasis, respectively, were compared and correlated to the corresponding values of the automated refraction.
Results: PPR values obtained in mydriasis were less myopic than in miosis. The sphere of PPR differed by an average of +0.23±0.3 diopters (-1.5 to +0.8 diopters) when using tropicamide 0.5 % + phenylephrine 2.5%. With tropicamid 0.5 % eye drops the difference was +0.22±0.7 diopters (-1.12 diopters to +0.6 diopters). The cylinder and the axis remained unchanged. The age of the patient had no influence on the amount of the difference. Automated refraction yielded a smaller difference of +0.16±0.3 diopters (tropicamide 0.5% + phenylephrine 2.5%) and +0.13±0.3 diopters (tropicamide 0.5%). Cylinder and axis were unchanged.
Conclusions: The cycloplegic effect of mydriatic eye-drops should be taken into account when interpreting aberration measurements and planning a wavefront-guided ablation.

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