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AbstractDO.01.11 Hemoglobin oxygenation of retinal vessels in artery occlusions over time and correlation with clinical outcome Gehlert S., Dawczynski J., Hammer M., Strobel J.
Universitätsklinikum Jena, Klinik für Augenheilkunde Objective: Evaluation of a new method for the measurement of hemoglobin oxygenation in retinal vessels. Patients with retinal artery occlusion have been measured before and after a rheological therapy.
Methods: The measurement of hemoglobin oxygenation in retinal vessels was made with a modified dynamic vessel analyser (Fa. Imedos, Jena). This module uses a special filter (transmission at 548 and 610 nm, bandwidth 10nm). Fundus images were acquired by a colour CCD camera and special software was used for vessels tracking and calculation of their haemoglobin oxygen saturation. 10 patients (5 branch and 5 central retinal artery occlusions, average age 54,4±8,8 and 68,8±3,7 years) were investigated at the time of diagnosis and at the 6th day of a rheological and intraocular pressure reduction therapy.
Results: 9 out of 10 patients have shown an increase of haemoglobin oxygenation over time. In patients with branch retinal artery occlusion the haemoglobin oxygenation increased considerably (on average from 62±11% to 90±16%), in central retinal artery occlusions from 95±7% to 98±12%, whereby venous haemoglobin oxygenation increased from 58±15% to 71±28%. Although haemoglobin oxygenation showed a clear increase for the first group, the visual acuity improved on average for less than one line. In contrast, the visual acuity of patients of the second group improved by up to four lines, however starting from low baseline values.
Conclusions: We showed a wide variety of hemoglobin oxygenation in occluded retinal arteries. One possible reason of the improvement of the hemoglobin oxygenation by the therapy may be an increase of the rheological properties of the blood. The majority of all patients showed an increase or at least a stabilisation of the visual acuity. Retinal vessel oximetry might be used as an additional parameter in the follow-up of retinal artery occlusion.
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